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KMID : 0043320100330050675
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Archives of Pharmacal Research
2010 Volume.33 No. 5 p.675 ~ p.680
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Biological Activity of Chemical Constituents from Clausena harmandiana
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Yenjai Chavi
Thongthoom Tula
Songsiang Uraiwan
Phaosiri Chanokbhorn
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Abstract
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The activity guided fractionation of the Clausena harmandiana root extracts led to the isolation of a coumarin, a ferulate, and eight carbazoles. This is the first report of the isolation of compounds 2-4 and 6-10 from this species, and this is the first time 10 was isolated from this genus. Compound 4 showed strong cytotoxicity against NCI-H187 cells with an IC50 value of 1.63 μg/mL. Compound 5 demonstrated strong cytotoxicity against MCF-7 and KB cell lines with IC50 values of 2.21 and 1.74 μg/mL, respectively. Compounds 3 and 4 exhibited moderate cytotoxicity against the MCF-7 cell line, and 8 showed moderate cytotoxicity against NCIH187 and KB cell lines. Compounds 3 and 5 showed antiplasmodial activity with IC50 values of 3.27 and 2.94 μg/mL, respectively.
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KEYWORD
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Clausena harmandiana, Cytotoxicity, Antimalaria, Anti-TB, Antifungal
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